Arrestin beta 2

ARRB2
Tanımlayıcılar
Digər adları	ARRB2, ARB2, ARR2, BARR2, Arrestin beta 2
Xarici ID-lər	OMIM: 107941 MGI: 99474 HomoloGene: 3183 GeneCards: ARRB2
Genin yeri (İnsan) Xromosom Xromosom 17 (insan)[1] Lokus 17p13.2 Başlanğıc 4,710,596 cb[1] Son 4,721,499 bp[1]
Genin yeri (Siçan) Xromosom Xromosom 11 (siçan)[2] Lokus 11 B3|11 42.99 cM Başlanğıc 70,323,461 bp[2] Son 70,331,654 bp[2]
RNT ifadəsi İfadə məlumatı üçün daha çox istinad
Gen ontologiyası Molekulyar funksiya • alpha-1B adrenergic receptor binding • 14-3-3 protein binding • protein kinase B binding • GO:0001948, GO:0016582 protein binding • enzyme binding • angiotensin receptor binding • GO:0032947 molecular adaptor activity • signaling receptor binding • G protein-coupled receptor binding • ubiquitin protein ligase binding • identical protein binding • arrestin family protein binding • GO:0032403 protein-containing complex binding • protein domain specific binding • alpha-1A adrenergic receptor binding • type 1 angiotensin receptor binding • D1 dopamine receptor binding • follicle-stimulating hormone receptor binding • type 2A serotonin receptor binding • platelet activating factor receptor binding • mitogen-activated protein kinase binding Hücrəsəl komponent • Sitoplazma • cytosol • postsynaptic membrane • GO:0097483, GO:0097481 postsynaptic density • membrane • Membran • endocytic vesicle • dendritic spine • intracellular anatomical structure • basolateral plasma membrane • clathrin-coated pit • GO:0016023 cytoplasmic vesicle • Hüceyrə nüvəsi • intracellular membrane-bounded organelle • endosome Bioloji proses • proteasome-mediated ubiquitin-dependent protein catabolic process • positive regulation of calcium ion transport • regulation of protein phosphorylation • negative regulation of interleukin-1 beta production • negative regulation of protein kinase B signaling • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • positive regulation of protein kinase B signaling • positive regulation of protein phosphorylation • endocytosis • regulation of G protein-coupled receptor signaling pathway • positive regulation of receptor internalization • negative regulation of release of cytochrome c from mitochondria • negative regulation of interleukin-6 production • receptor internalization • transcription by RNA polymerase II • positive regulation of peptidyl-serine phosphorylation • detection of temperature stimulus involved in sensory perception of pain • follicle-stimulating hormone signaling pathway • platelet activation • dopamine receptor signaling pathway • negative regulation of protein ubiquitination • brain development • GO:0034259 negative regulation of GTPase activity • negative regulation of toll-like receptor signaling pathway • protein ubiquitination • positive regulation of DNA biosynthetic process • positive regulation of ERK1 and ERK2 cascade • positive regulation of peptidyl-tyrosine phosphorylation • cell chemotaxis • protein transport • negative regulation of natural killer cell mediated cytotoxicity • regulation of androgen receptor signaling pathway • positive regulation of synaptic transmission, dopaminergic • negative regulation of tumor necrosis factor production • negative regulation of signal transduction • positive regulation of protein ubiquitination • transforming growth factor beta receptor signaling pathway • negative regulation of NF-kappaB transcription factor activity • negative regulation of smooth muscle cell apoptotic process • desensitization of G protein-coupled receptor signaling pathway by arrestin • GO:0072468 signal transduction • adult walking behavior • negative regulation of interleukin-12 production • Wnt signaling pathway, planar cell polarity pathway • GO:0033128 negative regulation of protein phosphorylation • G protein-coupled receptor internalization • GO:1901313 positive regulation of gene expression • protein deubiquitination • membrane organization • positive regulation of cardiac muscle cell differentiation • G protein-coupled receptor signaling pathway • excitatory postsynaptic potential • positive regulation of collagen biosynthetic process • GO:1904089 negative regulation of neuron apoptotic process • positive regulation of epithelial cell apoptotic process Sources:Amigo / QuickGO
Ortoloqlar
Species	Human	Mouse
Entrez	409	216869
Ensembl	ENSG00000141480	ENSMUSG00000060216
UniProt	P32121	Q91YI4
RefSeq (mRNA)	NM_001257328 NM_001257329 NM_001257330 NM_001257331 NM_004313 NM_199004 NM_001330064	NM_001271358 NM_001271359 NM_001271360 NM_145429
RefSeq (protein)	NP_001244257 NP_001244258 NP_001244259 NP_001244260 NP_001316993 NP_004304 NP_945355	NP_001258287 NP_001258288 NP_001258289 NP_663404
Yeri (UCSC)	Chr 17: 4.71 – 4.72 Mb	Chr 11: 70.32 – 70.33 Mb
PubMed axtarışı	[3]	[4]
Wikidata
İnsanı göstər/redaktə et Siçanı göstər/redaktə et

Arrestin beta 2, həmçinin arrestin beta-2 olaraq da bilinir — insanlarda ARRB2 geni ilə kodlanan hüceyrədaxili zülal.

Arrestin beta 2 zülal ailəsinin üzvlərinin G zülalı ilə əlaqəli reseptorların agonist vasitəçiliyi ilə desensitizasiyasında iştirak etdiyi və hormonlar, neyrotransmitterlər və ya duyğu siqnalları kimi stimullara hüceyrə reaksiyalarının spesifik şəkildə yatırılmasına səbəb olduğu düşünülür.^[5][6][7] Arrestin beta 2 zülalı həmçinin müstəqil siqnal roluna malikdir.^{[8][9][10][11][12]}

Arrestin beta 2, arrestin beta 1 kimi, beta-adrenergik reseptor funksiyasını in vitro inhibe edir. Mərkəzi sinir sistemində yüksək səviyyədə ifadə edilir və sinoptik reseptorların tənzimlənməsində rol oynaya bilər.

Beyinlə yanaşı, arrestin beta 2 üçün tamamlayıcı DNT^[13] qalxanabənzər vəzindən təcrid edilmişdir və beləliklə, o, tirotropin reseptorlarının hormon-spesifik desensitizasiyasında da iştirak edə bilər. Bu gen üçün bir çox alternativ olaraq birləşdirilmiş transkript variantları tapılmışdır, lakin bəzi variantların tam aydın təbiəti müəyyən edilməmişdir.[13]

Zülal 5-HT2A reseptor^[14] siqnalında agonist DOI^[15] ilə qarşılıqlı əlaqədə ola bilər.^[16][17]

Arrestin beta 2 morfin və digər opioidlərə^[18] qarşı dözümlülüyün inkişafı üçün vacibdir.

1. ↑ ^{1 2 3} GRCh38: Ensembl release 89: ENSG00000141480 - Ensembl, May 2017
2. ↑ ^{1 2 3} GRCm38: Ensembl release 89: ENSMUSG00000060216 - Ensembl, May 2017
3. ↑ "Human PubMed Reference:".
4. ↑ "Mouse PubMed Reference:".
5. ↑ Breivogel CS, Lambert JM, Gerfin S, Huffman JW, Razdan RK. "Sensitivity to delta9-tetrahydrocannabinol is selectively enhanced in beta-arrestin2 -/- mice". Behavioural Pharmacology. 19 (4). July 2008: 298–307. doi:10.1097/FBP.0b013e328308f1e6. PMC 2751575. PMID 18622177.
6. ↑ Li Y, Liu X, Liu C, Kang J, Yang J, Pei G, Wu C. "Improvement of morphine-mediated analgesia by inhibition of β-arrestin2 expression in mice periaqueductal gray matter". International Journal of Molecular Sciences. 10 (3). March 2009: 954–63. doi:10.3390/ijms10030954. PMC 2672012. PMID 19399231.
7. ↑ Zheng H. "Beta-arrestin-dependent mu-opioid receptor-activated extracellular signal-regulated kinases (ERKs) Translocate to Nucleus in Contrast to G protein-dependent ERK activation". Molecular Pharmacology. 73 (1). January 2008: 178–90. doi:10.1124/mol.107.039842. PMC 2253657. PMID 17947509.
8. ↑ Ma L, Pei G. "Beta-arrestin signaling and regulation of transcription". Journal of Cell Science. 120 (Pt 2). January 2007: 213–8. doi:10.1242/jcs.03338. PMID 17215450.
9. ↑ Defea K. "Beta-arrestins and heterotrimeric G-proteins: collaborators and competitors in signal transduction". British Journal of Pharmacology. 153 Suppl 1 (S1). March 2008: S298–309. doi:10.1038/sj.bjp.0707508. PMC 2268080. PMID 18037927.
10. ↑ Barki-Harrington L, Rockman HA. "Beta-arrestins: multifunctional cellular mediators". Physiology. 23. February 2008: 17–22. doi:10.1152/physiol.00042.2007. PMID 18268361.
11. ↑ Patel PA, Tilley DG, Rockman HA. "Physiologic and cardiac roles of beta-arrestins". Journal of Molecular and Cellular Cardiology. 46 (3). March 2009: 300–8. doi:10.1016/j.yjmcc.2008.11.015. PMID 19103204.
12. ↑ Golan M, Schreiber G, Avissar S. "Antidepressants, beta-arrestins and GRKs: from regulation of signal desensitization to intracellular multifunctional adaptor functions". Current Pharmaceutical Design. 15 (14). 2009: 1699–708. doi:10.2174/138161209788168038. PMID 19442183.
13. ↑ "Arxivlənmiş surət". 2021-06-07 tarixində arxivləşdirilib. İstifadə tarixi: 2023-09-20.
14. ↑ "Arxivlənmiş surət". 2023-09-03 tarixində arxivləşdirilib. İstifadə tarixi: 2023-09-21.
15. ↑ "Arxivlənmiş surət". 2023-08-26 tarixində arxivləşdirilib. İstifadə tarixi: 2023-09-21.
16. ↑ Schmid CL, Raehal KM, title = Agonist-directed signaling of the serotonin 2A receptor depends on beta-arrestin-2 interactions in vivo. Proceedings of the National Academy of Sciences of the United States of America. 105 (3). January 2008: 1079–84. doi:10.1073/pnas.0708862105. PMC 2242710. PMID 18195357 //www.ncbi.nlm.nih.gov/pmc/articles/PMC2242710 (#bare_url_missing_title). (#missing_pipe); (#vancouver)
17. ↑ Abbas A. "Arresting serotonin". Proceedings of the National Academy of Sciences of the United States of America. 105 (3). January 2008: 831–2. Bibcode:2008PNAS..105..831A. doi:10.1073/pnas.0711335105. PMC 2242676. PMID 18195368.
18. ↑ "Arxivlənmiş surət". 2023-08-31 tarixində arxivləşdirilib. İstifadə tarixi: 2023-09-21.